Volume 7, Number 1

Abstinence, Anticipation, Reduction, and Treatment (AART): A Stepwise Approach to the Management of Atypical Antipsychotic Side Effects
Doctors and patients alike are all for minimizing the side effects of atypical, or second-generation, antipsychotics. Dr. Annette Kennedy and her colleagues have established concrete criteria for evaluating medication side effects, a systematic approach they call AART. Read More

Single Enantiomer Drugs: Should They Be Developed?
We all know that sometimes less is more. As Drs. Khan, Preskorn, and Wimalasena see it, the same may be true for pharmaceuticals. In Why and How to Develop Single Enantiomeric Drugs, they present a persuasive argument for the potential attributes of a single chemical entity, or enantiomer, to as opposed to mixed chemical agents, or racemic drugs, which include increased potency, decreased side effects, and greater overall value for cost. Read More

Anxious-Depressive Comorbidity: Effects on HPA Axis and CNS Noradrenergic Functions
The close relationship between depression and anxiety has been well-established, and equally well-documented. According to Dr. Cameron, the rate of comorbidity between the two is as high as 25%-50%, indicating that the one disorder may not be independent of the other. Read More

Serotonin and Norepinephrine Transporter Binding Profile of SSRIs
Drs. Gutman and Owens' special report challenges the accepted wisdom comparing the relevance of the affinity and selectivity of SSRIs for serotonin transporters and norepinepjrine transporters. Ths report presents their pioneering data and raises some interesting questions about the efficacy of antidepressants. Read More

Special Report
Cytokines and Late-life Depression
We've all heard the question: "Where does depression hurt?" But what if the older you are, the more you just feel sick? Drs. Craddock and Thomas explore the role of the immune system in depression in Cytokines and Late-Life Depression, including the relationship between the body, the mind, and the aging process. Read More

Feature Interview
The CATIE Study and Its Implications for Antipsychotic Drug Use
The CATIE Study and Its Implications For Antipsychotic Use, an interview by Editor-in-Chief, Frederic Flach, MD, with Dr. Philip R. Janicak, scrutinize the latest Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) study in terms of its scope, its objectives, its limitations and its ramifications for patients with schizophrenia and their doctors. Read More